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ERA-NET PathoGenoMics

    Transnational Cooperation

    ERA-NET PathoGenoMics

    FCT is a partner of PathoGenoMics(PGM), an ERA-NET that started in 2004 with the participation of 15 partners from 10 European countries (Portugal, Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia, and Spain), which have cooperated to promote and fund transnational research in genomics of microorganisms that cause disease in humans (with special emphasis on genomic studies of bacteria and fungi) and the implementation of the European Research Area (ERA).

    PGM opened three transnational calls (2006, 2008, and 2010) with a total budget of 46 M€. Part of the budget was dedicated to consortia in which all principle investigators where young researchers (minimum of 2/maximum of 9 years after the PhD). A total of 144 pre-proposals were submitted to the 3 calls, 34 of which were funded, with a success rate of 23,6 %. 11 of the 34 funded consortia have Portuguese teams and one of them is coordinated by a Portuguese young investigator. FCT participated in all calls funding projects in total amount of approximately 1,37 M€.


      Calls
      2006 2008 2010
    Proposals submitted – Total 44 50 50
    Proposals submitted – PT 11 9 15
    Partnerships 217 286 253
    Countries/Regions 8 9 8
    Funded projects – Total 12 13 9
    Funded projects – PT 4 3 5
    Funding – Total 16,6 M€ 16,3 M€ 9,0 M€
    Funding – PT 0,46 M€ 0,42 M€ 0,49 M€
    Partnerships 85 77 49
    Success rate – Total 27 % 26 % 18 %
    Success rate – PT 36 % 33 % 33 %

    Funded projects with Portuguese participation

    CALL 2010

    • Analysis of the cellular mechanisms underlying the early response of the host to stress induced by Listeria infection. Led in Portugal by Didier Cabanes (IBMC), with a total budget for 3 years of 100 000 €.

    • Helicobacter pylori diversity in pathogenesis, antibiotic resistance, and evasion from natural and vaccine-induced immune responses. Led in Portugal by José Carlos Machado (IPATIMUP), with a total budget for 3 years of 100 000 €.

    • Global analysis of antisense regulatory mechanisms in Staphylococcus aureus. Led in Portugal by Susana Domingos (ITQB), with a total budget for 3 years of 87 500€.

    • Characterisation of host cell pathways altered by effectors of Brucella, Chlamydia, and Coxiella: identification of novel therapeutic targets. Project with Portuguese coordination led by Jaime Mota (ITQB) and with the participation of another Portuguese team led by João Paulo Domingues (INSA), with a total budget for 3 years of 200 000 €.


    CALL 2008

    • ADHRES-Signature Project. Led in Portugal by Isabel Sá-Correia (IST), with a total budget for 3 years of 93 432 €.

    • Pathogenomic of increased Clostridium difficile virulence. Led in Portugal by Adriano Henriques (ITQB), with a total budget for 3 years of 181 800 €.

    • Development, prevention and early diagnostic detection of Clostridium difficile-associated pseudomembranous colitis-an interdisciplinary network. Led in Portugal by Miguel Godinho Lifewizz Lda., with a total budget for 3 years of 142 000 €.


    CALL 2006

    • Parasite and host genetic diversity in Helicobacter infections. Led in Portugal by José Carlos Machado (IPATIMUP), with a total budget for 3 years of 95 000 €.

    • Large scale screening of potential key factors involved in the commensalism/virulence transition of Enterococcus faecali. Led in Portugal by Maria de Fátima Silva Lopes (ITQB), with a total budget for 3 years of 86 435 €.

    • A global RNAi approach to unravel eukaryotic host functions that modulate bacterial infections. Led in Portugal by Céu Figueiredo (IPATIMUP), with a total budget for 3 years of 180 000 €.

    • Spatio-temporal analysis of Listeria-host protein interactions. Led in Portugal by Didier Cabanes (IBMC), with a total budget for 3 years of 112 962 €.


    Awards

    One of the goals of PGM was to promote and encourage the training of human resources in genomics of microorganisms that cause disease in humans. In this context, between 2004 and 2012, were opened 6 competitions to reward the best doctoral theses in this area. Each selected student received a prize of 2,000 €, the participation in an international meeting and the oral presentation of the work. During this period PGM awarded 18 thesis, three of which were from Portuguese researchers:

    João Paulo Gomes (2007): “Contribution for the understanding of biological differences among Chlamydia trachomatis serovars using genomics and transcriptomics”.
    Cristina Dias Rodrigues (2008): “Revealing Host Factors Important for Hepatocyte Infection by Plasmodium”.
    Alexandra Isabel Cardoso Nunes (2010): “Genomic and Transcriptomic Features of Chlamydia trachomatis: Tracking the Basis for the Ecological Success”.


    Databases and other initiatives

    PGM has developed several other initiatives to promote and stimulate collaboration and exchange of ideas between academics, clinicians and entrepreneurs, as:
    Database of Researchers
    Database of SMEs
    Map of the next generation sequencers



    Contacts

    Anabela Isidro
    anabela.isidro@fct.pt
    Ph.: (351) 21 391 15 52

    Catarina Resende
    catarina.resende@fct.pt
    Ph.: (351) 21 392 44 56

    FCT – Fundação para a Ciência e a Tecnologia
    Av. D. Carlos I, 126
    1249 – 074 LISBOA
    Portugal

    ERA-NET PathoGenoMics website

    http://www.pathogenomics-era.net/