FCT is a partner of PathoGenoMics(PGM), an ERA-NET that started in 2004 with the participation of 15 partners from 10 European countries (Portugal, Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia, and Spain), which have cooperated to promote and fund transnational research in genomics of microorganisms that cause disease in humans (with special emphasis on genomic studies of bacteria and fungi) and the implementation of the European Research Area (ERA).
PGM opened three transnational calls (2006, 2008, and 2010) with a total budget of 46 M€. Part of the budget was dedicated to consortia in which all principle investigators where young researchers (minimum of 2/maximum of 9 years after the PhD). A total of 144 pre-proposals were submitted to the 3 calls, 34 of which were funded, with a success rate of 23,6 %. 11 of the 34 funded consortia have Portuguese teams and one of them is coordinated by a Portuguese young investigator. FCT participated in all calls funding projects in total amount of approximately 1,37 M€.
|Proposals submitted – Total||44||50||50|
|Proposals submitted – PT||11||9||15|
|Funded projects – Total||12||13||9|
|Funded projects – PT||4||3||5|
|Funding – Total||16,6 M€||16,3 M€||9,0 M€|
|Funding – PT||0,46 M€||0,42 M€||0,49 M€|
|Success rate – Total||27 %||26 %||18 %|
|Success rate – PT||36 %||33 %||33 %|
• Analysis of the cellular mechanisms underlying the early response of the host to stress induced by Listeria infection. Led in Portugal by Didier Cabanes (IBMC), with a total budget for 3 years of 100 000 €.
• Helicobacter pylori diversity in pathogenesis, antibiotic resistance, and evasion from natural and vaccine-induced immune responses. Led in Portugal by José Carlos Machado (IPATIMUP), with a total budget for 3 years of 100 000 €.
• Global analysis of antisense regulatory mechanisms in Staphylococcus aureus. Led in Portugal by Susana Domingos (ITQB), with a total budget for 3 years of 87 500€.
• Characterisation of host cell pathways altered by effectors of Brucella, Chlamydia, and Coxiella: identification of novel therapeutic targets. Project with Portuguese coordination led by Jaime Mota (ITQB) and with the participation of another Portuguese team led by João Paulo Domingues (INSA), with a total budget for 3 years of 200 000 €.
• ADHRES-Signature Project. Led in Portugal by Isabel Sá-Correia (IST), with a total budget for 3 years of 93 432 €.
• Pathogenomic of increased Clostridium difficile virulence. Led in Portugal by Adriano Henriques (ITQB), with a total budget for 3 years of 181 800 €.
• Development, prevention and early diagnostic detection of Clostridium difficile-associated pseudomembranous colitis-an interdisciplinary network. Led in Portugal by Miguel Godinho Lifewizz Lda., with a total budget for 3 years of 142 000 €.
• Parasite and host genetic diversity in Helicobacter infections. Led in Portugal by José Carlos Machado (IPATIMUP), with a total budget for 3 years of 95 000 €.
• Large scale screening of potential key factors involved in the commensalism/virulence transition of Enterococcus faecali. Led in Portugal by Maria de Fátima Silva Lopes (ITQB), with a total budget for 3 years of 86 435 €.
• A global RNAi approach to unravel eukaryotic host functions that modulate bacterial infections. Led in Portugal by Céu Figueiredo (IPATIMUP), with a total budget for 3 years of 180 000 €.
• Spatio-temporal analysis of Listeria-host protein interactions. Led in Portugal by Didier Cabanes (IBMC), with a total budget for 3 years of 112 962 €.
One of the goals of PGM was to promote and encourage the training of human
resources in genomics of microorganisms that cause disease in humans. In this
context, between 2004 and 2012, were opened 6 competitions to reward the best
doctoral theses in this area. Each selected student received a prize of 2,000
€, the participation in an international meeting and the oral presentation of
the work. During this period PGM awarded 18 thesis, three of which were from
• João Paulo Gomes (2007): “Contribution for the understanding of biological differences among Chlamydia trachomatis serovars using genomics and transcriptomics”.
• Cristina Dias Rodrigues (2008): “Revealing Host Factors Important for Hepatocyte Infection by Plasmodium”.
• Alexandra Isabel Cardoso Nunes (2010): “Genomic and Transcriptomic Features of Chlamydia trachomatis: Tracking the Basis for the Ecological Success”.
PGM has developed several other initiatives to promote and stimulate
collaboration and exchange of ideas between academics, clinicians and
• Database of Researchers
• Database of SMEs
• Map of the next generation sequencers
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