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R&D Projects

Scientific Research and Technological Development Projects - 2014

Biomedicine Evaluation Panel - 2014

Coordination

Jan Borén
The Wallenberg Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden, Sweden

Evaluation

Adrian Chabowski
Department of Physiology, Medical University of Bialystok, Bialystok, Poland
Ahmed Ashour Ahmed
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, United Kingdom
Alison Lloyd
Medical Research Council (MRC) Laboratory for Molecular Cell Biology, University College London (UCL), United Kingdom
Andrew H. Baker
Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
Bohdan Wasylyk
Institute of Genetics and Molecular and Cellular Biology (IGBMC), France
Costanza Emanueli
Bristol CardioVascular (BCV), University of Bristol, United Kingdom
David Waugh
Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom
Eduardo Moreno
Institute of Cell Biology, University of Bern, Switzerland
Erik Danen
Faculty of Science, Leiden Academic Centre for Drug Research, Toxicology, Gorlaeus Laboratories, Netherlands
Fabio Virgili
Council for Agricultural Research and Economics, Food and Nutrition Research Centre, (C.R.A.- NUT), Italy
Francesca Buffa
Dept of Oncology & Weatherall Institute of Molecular Medicine, United Kingdom
Ingrid Fleming
Vascular Research Centre, Frankfurt am Main, Germany
Klaus Elenius
Department of Medical Biochemistry and Genetics, University of Turku, Finland
Luc Buee
Jean-Pierre Aubert Research Centre, University of Lille, France
Marcin Majka
Department of Clinical Immunology and Transplantation, Collegium Medicum of the Jagiellonian University, Poland
Richard Moriggl
Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Austria

Projects assigned

PTDC/BIM-ONC/0016/2014

Novel tumorigenic mechanisms of aberrant epigenetic regulation in clear cell renal cell carcinoma
SÉRGIO ALEXANDRE FERNANDES DE ALMEIDA
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/0155/2014

Unraveling a Novel Mechanism of Resistance to Targeted melanoma Therapies
Wolfgang Link
Universidade do Algarve (UAlg)

PTDC/BIM-ONC/0166/2014

Resistance Enhanced by SOX2-Induced Stemness Traits in cancer
Raquel Maria da Silva Graça Almeida
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/0195/2014

NanoAntiMito: Therapeutic targeting of cell division through functionalized nanoparticle-mediated siRNA delivery for the treatment of lung cancer
Hassan Bousbaa
Cooperativa de Ensino Superior Politécnico e Universitário, CRL (CESPU)

PTDC/BIM-ONC/0200/2014

NewInsigtStrategy for Cholangicarcinoma
José Guilherme Lopes Rodrigues Tralhão
Universidade de Coimbra (UC)

P2020-PTDC/BIM-ONC/0281/2014

Sensing dysfunctional E-cadherin cells in gastric epithelia (SENSE)
Raquel Seruca
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/0345/2014

STEAP1- A promising therapeutic target and a biomarker for prostate cancer
Cláudio Jorge Maia Baptista
Universidade da Beira Interior (UBI)

PTDC/BIM-ONC/0357/2014

An omics approach to identify the effects of a high-saturated-fat diet in the mammary gland and in breast cancer growth
Luisa Alejandra Helguero
Universidade de Aveiro (UA)

PTDC/BIM-ONC/0794/2014

Phospholipase C Signalling Network in Colorectal Cancer
Marta Sofia Alves Martins
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/0919/2014

Hyperbaric Photodynamic Therapy for Retinoblastoma
Ana Margarida Coelho Abrantes
Universidade de Coimbra (UC)

PTDC/BIM-ONC/1019/2014

Preclinical testing of a new therapeutic approach for glioblastoma treatment: coupling a new hybrid compound with glioma-targeted nanoparticles
Ana Sofia Iria Azeredo Falcão de Jesus
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-ONC/1252/2014

Glioblastoma cells: role of the microenvironment and therapeutic targeting
Maria Celeste Fernandes Lopes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/1299/2014

Peritoneal carcinomatosis of ovarian cancer: molecular mechanisms and strategies for inhibition
Maria Leonor Martins Soares David
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/1566/2014

Characterizing the biological role of clinically relevant collagen type I fragments in bone metastatic disease
Luis Antonio Marques da Costa
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/1657/2014

Waves of DNA strand break/repair are intrinsic, normal part of inducible cell proliferation
Birgit Arnholdt-Schmitt
Universidade de Évora (UE)

PTDC/BIM-ONC/1946/2014

Targeting estrogen receptor (ER)-dependent genes to predict and prevent bone relapse in hormone dependent breast cancer
Sandra Cristina Cara de Anjo Casimiro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/1955/2014

Deciphering the tumorigenic role of the tumour suppressor gene SPINT2 silencing in solid tumours
MARTA SOFIA DE CARVALHO RIBEIRO VIANA PEREIRA
Universidade do Minho (UM)

PTDC/BIM-ONC/2237/2014

miRNA in Colorectal Cancer: how far can we go?
Marta Susana de Almeida Viegas da Silva
Instituto Português de Oncologia de Francisco Gentil, Centro Regional de Oncologia de Coimbra (IPO Coimbra)

PTDC/BIM-ONC/2272/2014

Targeting metastatic reprogramming of breast tumour cells via the novel Rac1/PAK1/BCL6/STAT5 pathway
Patrícia Alexandra de Sousa Barros
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-ONC/2275/2014

The role of inflammatory cytokine signaling in the alternative splicing of tumor-related Rac1b
Vânia Marina Cristóvão Gonçalves
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-ONC/2455/2014

Ovarian cancer a model to define genomic and epigenomic analysis as a tool to predict chemoresistance
Jacinta de Fatima Ro/sario Serpa
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/2522/2014

New therapeutic targets in prostate cancer: role of the phosphoprotein phosphatase 1 complexes
Luis Korrodi Mineiro Marques Gregório
Universidade de Aveiro (UA)

PTDC/BIM-ONC/2714/2014

Unravelling the molecular mechanisms underlying 3-bromopyruvate (3BP) efficacy in cancer
Odilia Queiros
Universidade do Minho (UM)

P2020-PTDC/BIM-ONC/2754/2014

The Role of Exosomes in Tumor Heterogeneity: More than Just Bubbling
Sonia Melo
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/2770/2014

Tumor-macrophage metabolic crosstalk: unraveling the role of monocarboxylate transporters (MCTs)/CD147
Maria de Fátima Monginho Baltazar
Universidade do Minho (UM)

PTDC/BIM-ONC/2779/2014

A healing breath: aerosolized nanoparticles targeted for lung cancer
Mafalda Sofia Laranjo Cândido
Universidade de Coimbra (UC)

PTDC/BIM-ONC/2825/2014

Disclosing the mechanism of vessels disruption by propranolol and its metabolites in brain tumours
Germana Andreia Taipa Leandro Domingues
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/2847/2014

Changing melanoma cell metabolism to improve melanoma therapy
Helena Isabel Martins Pópulo
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/2870/2014

Checkpoint mediator Claspin: role in cell homeostasis, oncogenesis and response to therapy
Teresa Maria Caldeira Martins
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/3186/2014

Understanding the role of miR-200c in the development and progression of breast cancer
António Sebastião Rodrigues
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/3402/2014

Age as a carcinogen: is telomere-shortening the culprit?
Miguel Godinho Ferreira
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-ONC/3486/2014

Gassing the gas: Understanding and targeting hydrogen sulfide metabolism in colorectal cancer
João Filipe Bogalho Vicente
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

PTDC/BIM-ONC/3589/2014

Damage-associated-molecular-patterns (DAMPs) as targets for melanoma therapy
Carlos Manuel Mendes Novo
Instituto de Higiene e Medicina Tropical (IHMT/UNL)

PTDC/BIM-ONC/3832/2014

Targeting Macrophages at Colorectal Cancer Primary Tumor and Metastases
Maria José Cardoso Oliveira
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-ONC/3862/2014

IDENTIFICATION AND VALIDATION OF ACTIONABLE MOLECULAR TARGETS FOR MULTIMODAL THERAPY OF GASTRIC CANCER PATIENTS
Carla Oliveira
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/4127/2014

Genetic variants in the vitamin D pathway and risk of thyroid cancer
Manuel Lemos
Universidade da Beira Interior (UBI)

PTDC/BIM-ONC/4452/2014

Preclinical evaluation of a novel treatment for malignant gliomas based on trispecific 5T4-EGFRvIII-CD3 T-cell engager antibodies
Bruno Costa
Universidade do Minho (UM)

PTDC/BIM-ONC/4759/2014

IL-7/IL-7R signaling networks in health and malignancy
João Pedro Taborda Barata
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/4886/2014

How lipid biosynthesis impacts in cancer progression
Sérgio Dias
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/4890/2014

Studying and targeting the non-canonical translation of p53 isoforms during stress and carcinogenesis
Marco Candeias
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/BIM-ONC/4950/2014

MicroRNAs expression profile in Hepatocellular Carcinoma: Potential prognostic and therapeutic value
Jose Manuel Borges Nascimento Costa
Universidade de Coimbra (UC)

PTDC/BIM-ONC/4972/2014

Targeting RAC1b-signaling to enhance iodide-related therapy in thyroid and breast malignancies
Ana Luísa Silva
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE (IPO Lisboa)

PTDC/BIM-ONC/4978/2014

Notch3 function in oncology recapitulates ontegeny and represents a potential therapeutic target for prostate cancer
Alexandre José Neto Trindade
Faculdade de Medicina Veterinária (FMV/ULisboa)

PTDC/BIM-ONC/5044/2014

The crossroads between diabetes/obesity and acute myeloid leukemia
PAULA CRISTINA DA COSTA ALVES MONTEIRO LUDOVICO
Universidade do Minho (UM)

PTDC/BIM-ONC/5097/2014

OVERCOMING AGGRESSIVENESS AND CHEMORESISTANCE MEDIATED BY CD147 IN UROTHELIAL BLADDER CANCER
Adhemar Longatto
Universidade do Minho (UM)

PTDC/BIM-ONC/5203/2014

Embryonic T-box transcription factor Brachyury: Dissecting its role in prostate cancer biology and clinical application.
RUI MANUEL REIS
Universidade do Minho (UM)

PTDC/BIM-ONC/5318/2014

Evaluation of molecular and genetic heterogeneity in high-grade serous carcinoma of the female genital tract as a biomarker for predicting treatment resistance
José Manuel Pedrosa Baptista Lopes
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-ONC/5489/2014

Molecular crosstalk in the microenvironment of cancer: the role of thymic epithelial cells in T-cell acute lymphoblastic leukemia
Nuno Alexandre Pinto Rodrigues dos Santos
Universidade do Algarve (UAlg)

PTDC/BIM-ONC/5544/2014

Synchronic and metachronic breast and endometrial cancers. Tamoxifen effect as tool for endometrial carcinogenesis
Ana Maria Felix de Campos Pinto
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/5600/2014

Evaluation of ‘in vitro’ chemosensitivity and its correlation with ‘in vivo’ chemotherapy response in breast cancer patients who underwent neo-adjuvant treatment – UnIO 04.15
Ana Barbosa de Sousa Nogal
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-ONC/6163/2014

Clonal evolution driving Acute Myeloid Leukaemia relapse: Quantitative tracking of subclonal dynamics and single-cell characterization of tumour escape variants
Håkan Rolf Norell
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/6236/2014

“Androgen Receptor & MYC transcription factor targeting microRNAs in Prostate Cancer”
Rui Manuel Ferreira Henrique
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/BIM-ONC/6261/2014

Triple Negative Breast Cancer Screening and Role of DNA Repair Pathways
Susana Maria Nunes da Silva Duarte Catana
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/6533/2014

Staging the axilla after neoadjuvant chemotherapy with a targeted dissection using carbon-dye - A phase 2 study
Fatima Cardoso
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/BIM-ONC/6579/2014

The Role of Secreted Exosomes in Malignant Progression and Chemotherapy Response in Colorectal Cancer (CRC) Organoids
Carlos Alberto Torres de Carvalho
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/BIM-ONC/6697/2014

Isolation, purification and cryopreservation of human testicular stem cells
Rosália Sá
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-ONC/6730/2014

Male breast carcinogenesis
Maria da Saudade Pereira André
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/6858/2014

"Length matters: Causes and consequences of centriole length deregulation in cancer"
Monica Bettencourt Carvalho Dias
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-ONC/6897/2014

Role of estrogen receptors in schistosome-associated and non-schistosome associated bladder cancers
Lúcio Lara Santos
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/BIM-ONC/6937/2014

Genetic and epigenetic profiling of glioblastomas: towards an improvement of patient’s diagnosis, prognosis and personalized treatment
Maria do Rosário Pires Maia Neves de Almeida
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/7054/2014

Unraveling of key molecular pathways in adrenocortical tumors as promising treatment targets
Duarte Luis Pignatelli Dias Almeida
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

P2020-PTDC/BIM-ONC/7121/2014

Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma
José Francisco da Silva Cascalheira
Universidade da Beira Interior (UBI)

PTDC/BIM-ONC/7162/2014

Gene expression profile under β-adrenergic regulation: potential therapeutic target for gynecological tumors
Raquel Catarino
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/BIM-MEC/0042/2014

Unravelling the microbiota that drives gastric carcinogenesis
Ceu Figueiredo
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/0095/2014

A new molecular target in Machado-Joseph disease: Ataxin-2 as a translational regulator of mutant Ataxin-3

Clevio David Rodrigues Nobrega
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/0125/2014

Using Transthyretin (TTR) stabilization to modulate toxicity in Alzheimers Disease (AD) and dissecting the underlying protective mechanism of TTR in AD
Isabel dos Santos Cardoso
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0132/2014

Understanding the pathophysiology of chronic visceral pain.
Ana Cristina Estrela de Oliveira Charrua Cordeiro
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0146/2014

Testing Koch’s postulates in sporadic Parkinson’s disease
Sandra Morais Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/0264/2014

Tissue macrophages regulation of lung differentiation and maturation: implications in prematurity
SANDRA MARIA ARAÚJO DA COSTA
Universidade do Minho (UM)

PTDC/BIM-MEC/0280/2014

The Subtle channel: CaV3.1 involvement in nociception.
Ofelia Maria Vieira Pinto de Carvalho
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/0501/2014

Characterisation of anti-HDL antibodies: identification of their biologic activity, pathogenic potential and clinical relevance
Joana Rita Ramos Pires Batuca
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0502/2014

BREAKING THROUGH INNER NUCLEAR MEMBRANE PROTEINS
Sandra Maria Tavares da Costa Rebelo
Universidade de Aveiro (UA)

PTDC/BIM-MEC/0544/2014

Dissecting the role of alpha-synuclein phosphorylation in Parkinson’s disease
Sandra Isabel Nogueira Tenreiro
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0602/2014

Deconstructing stromal-epithelial interactions in colorectal cancer: understanding the parts to fight the whole (STEP-in)
SERGIA VELHO
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/0740/2014

Understanding the role of non-enzymatic serum protein glycation in iron toxicity related endothelial dysfunction in Diabetes Mellitus.
André Moreira Neto da Silva
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MEC/0895/2014

New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer
Cecília Maria Pereira Rodrigues
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/0908/2014

Redefining the neuropathology and unraveling the causality behind defects in the biosynthesis of plasmalogens
Pedro Miguel Teixeira Brites
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0990/2014

O papel do retículo endoplasmático na doença: utilização de moduladores do RE no cancro.
David Pereira
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MEC/1061/2014

Exploring miRNA deregulation in the context of neuroinflammation: from systemic biomarkers to therapeutic targets in Alzheimer´s disease
Ana Luísa Colaço Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/1095/2014

ER Stress in initial beta-cell dysfunction and neo-antigens formation in Type 1 Diabetes: opportunity to new immunotherapies
Bruno Miguel Rodrigues Neves
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/1118/2014

Targeting interactions in the Neurovascular Unit to find novel therapies for Alzheimer’s disease
Maria Alexandra de Oliveira Silva Braga Pedreira de Brito
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/1127/2014

Pathophysiology and clinical evaluation of severe proliferative diabetic retinopathy. A role for the ghrelin GHSR-1a system.
Amandio Rocha Sousa
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1137/2014

Unraveling the incomplete reverse remodeling-related proteome signature of the heart
Inês Falcão Pires
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1182/2014

Modelling GABAergc switch in Rett Syndrome
Cláudia Sofia Cardoso Gaspar
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1231/2014

Targeting hypothalamic sirtuin 2 to prevent metabolic disease
António Pedro Barros Gomes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/1271/2014

Molecular and cellular pathways associated with organ specific involvement in transthyretin amyloidosews: contribution for targeted therapies
Maria João Gameiro de Mascarenhas Saraiva
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/1289/2014

UNCOVERING THE CELL SPECIFIC ROLE OF THE Rho/ROCK PATHWAY ON THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS
Renato Socodato
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/1294/2014

A personalized approach to study genotype-phenotype relations in Hypertrophic Cardiomyopathy
Sandra Cristina Bento Penisga Martins
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1307/2014

Rescuing galactosemia phenotype with small molecules
Isabel Maria Antolin Martins-de-Carvalho
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/1342/2014

Evasion of host-mediated autophagy: mechanisms of Plasmodium survival in the liver-stage of infection
Maria Manuel Dias da Mota
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1381/2014

The etiology of atherogenesis: from bench work to the bed side
Otília Vieira
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/1457/2014

Why is CFTR stimulated in Autosomal Dominant Polycystic Kidney Disease?
Mónica Alexandra Roxo Cruz Rosa Iglésias
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/1514/2014

Src kinase signaling and glutamatergic postsynaptic dysfunction in Alzheimer’s disease
Ildete Luísa de Araújo Ferreira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/1531/2014

Bone Metastasis in Breast Cancer: establishing a combined inhibitory therapeutic approach
Daniela dos Santos Monteiro e Sousa
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MEC/1576/2014

Disclosing the molecular basis of protein aggregation and citotoxicity in beta-2-microglobulin amyloidosis
Patrícia Ferreira Neves Faísca
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-MEC/1597/2014

Angiogenic paradox in diabetes: Targeting Galectin-3
Raquel Soares
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1650/2014

Signaling pathways involved in the regulation of epithelial chloride transport
Peter Jordan
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-MEC/1702/2014

Dechipering the mechanisms underlying the loss of BDNF neuroprotection in Alzheimer's disease
Rita Cruz Coelho de Mira Ramalho
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

P2020-PTDC/BIM-MEC/1719/2014

Understanding the role of tRNA modifying enzymes in proteostasis in human health and disease.
Ana Raquel Santos Calhôa Mano Soares
Universidade de Aveiro (UA)

PTDC/BIM-MEC/1740/2014

Regaining control in spinal cord injury: molecular mechanisms of bladder dysfunction
Célia da Conceição Duarte Cruz
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1754/2014

Gunning for the Achilles Heel of Colon Cancer Stem Cells
Pedro Borralho
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/1823/2014

BREAK the CHAIN: Mitochondrial-directed Antioxidant to Prevent Anthracycline-induced Delayed Cardiomyopathy
Vilma Marisa Arrojado Soares Sardão Oliveira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/1824/2014

Integrative approach on perinatal asphyxia to unravel novel biomarkers
Cláudia Susana Fernandes Queiroga
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/1903/2014

Assessment of hepatic fibrosis in type II diabetes - antioxidant effect
Manuel Nuno de Magalhães Pinheiro Alçada
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1997/2014

Suppression of proteotoxicity by serotonergic signaling: dissecting the molecular effects of selective serotonin re-uptake inhbitors (SSRIs)
Andreia Cristiana Teixeira de Castro
Universidade do Minho (UM)

PTDC/BIM-MEC/1998/2014

Biology of infection in 3D: how obligatory intracellular Leishmania parasites subvert host cell mobility to promote dissemination.
Helena Maria de Sousa Castro
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/1999/2014

Dysfunction of GABAergic synapses in status epilepticus (SE): structural synaptic reorganization and changes in GABAA receptor dynamics
miranda mele
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/2085/2014

Pain biomarkers
Isabel Martins
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/2128/2014

Development of a Micro-Nano-Bio-system for optimizing studies of stem cells in advanced therapies
Abel Martin Gonzalez Oliva
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

PTDC/BIM-MEC/2131/2014

Novel Factors of CFTR Traffic Related to Epithelial Cell Differentiation: Potential Therapeutic Targets for Cystic Fibrosis
Margarida Sofia Pereira Duarte Amaral
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/BIM-MEC/2165/2014

The metabolic regulation of cancer cell migration and invasion
Jorge Filipe de Almeida Vieira Lima
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/2167/2014

The muscle as promotor of Spondyloartritis progression: a new paradigm.
Fernando Manuel Pimentel dos Santos
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/2171/2014

NLRP3 inflammasome activation as a bridge between diabetes and Alzheimer’s disease – a mechanistic insight
Paula Isabel da Silva Moreira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/2231/2014

NEUROCOGNITIVE DEVELOPMENT MODULATORS IN PHENILKETONURIC PATIENTS: THE IMPORTANCE OF BIOPSYCHOSOCIAL FACTORS IN DETERMINING THE PHENOTYPE
Carla Maria Carmona
Centro Hospitalar Universitário do Porto (CHP/MS)

PTDC/BIM-MEC/2305/2014

In vitro and in vivo studies to unravel mechanisms of disease involved in transthyretin (TTR) cardiac amyloidosis
Maria Rosário Almeida
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/2306/2014

Novel mechanisms for insulin resistance induced by glucocorticoids
Maria João Rodrigues Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/2318/2014

Anti-TNF therapy in Crohn´s disease: impact on macrophage phenotype, iron metabolism and autophagy
Amélia Maria Marques da Silva Rodrigues Sarmento Assunção
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/2340/2014

Unveilling molecular mechanisms behind placentation in obesity: relevance for development of pregnancy complications.
Henrique Almeida
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/2355/2014

Searching for the missing heritability of COPD and Lung Cancer diseases among genes of proteolysis
Susana Seixas
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/2388/2014

T cell approaches to decipher Common Variable Immunodeficiency
Rui Manuel Martins Victorino
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/2476/2014

Understanding Chronic Haemolysis Pathophysiology – from molecular mechanisms to therapeutic targets
MARIA PAULA DUARTE FAUSTINO GONÇALVES
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/BIM-MEC/2520/2014

Relaxin and heart failure with preserved ejection fraction: from the animal model to the patient
Paulo Manuel Castro Chaves
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/2551/2014

Cx43 fills the gap between miR-424 and heart hypertrophy: Smurf1-mediated impairment of GJIC as novel mechanism underlying Pulmonary Hypertension
Carla Isabel dos Santos Marques
Universidade de Coimbra (UC)

PTDC/BIM-MEC/2580/2014

Assessing cytoskeleton involvement in the pathogenesis of familial amyloid polyneuropathy
Márcia Raquel Pereira de Almeida e Liz
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/2626/2014

The role of NRARP in the pathogenesis of T-cell Acute Lymphoblastic Leukemia
Ana Rita Fragoso
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/2737/2014

Placental dysfunction and intrauterine growth restriction: unraveling the role of oxidative stress
Fátima Martel
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/2753/2014

UNDERSTANDING THE MECHANISMS BEHIND IMPAIRED CELLULAR RESILIENCE IN BIPOLAR DISEASE: TOWARDS NOVEL THERAPEUTIC TARGETS AND BIOMARKERS
Cláudia Maria Fragão Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/BIM-MEC/2834/2014

The yin and yang of somatic mutations in cancer immunosurveillance
José Carlos Lemos Machado
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/2850/2014

Hereditary Diffuse Gastric Cancer - beyond CDH1 coding mutations
Hugo Celso Pinheiro
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/2893/2014

Preventing loss of tight junction integrity in HIV/AIDS.
Russell Bourne Foxall
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/2929/2014

Protection against hemolytic conditions by the DNA damage response pathway
Ana Rita Cabral Martins Carlos
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/2943/2014

Cooperation between HLA-F and HLA-B27 in Ankylosing Spondylitis
Jacome Bruges Armas
Instituto de Biologia Molecular e Celular (IBMC/UP)

P2020-PTDC/BIM-MEC/2968/2014

Identification and functional characterization of microRNAs controlling cardiac ischemia-reperfusion injury
Miguel Luis Cunha Mano
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/2970/2014

PATHOGENESIS OF ARTHROPATHY IN HEREDITARY HEMOCHROMATOSIS: EXPLORING THE ROLE OF NOVEL DISEASE MODIFIERS
Maria da Graça Beça Gonçalves Porto
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/2984/2014

Role of Epicardial Adipose Tissue in Diabetic Cardiovascular Diseases
Eugenia Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/3117/2014

A molecular imaging approach to Cystic Fibrosis: in vivo detection of CFTR
Filipa Fernandes Mendes
Associação do Instituto Superior Técnico para a Investigação e o Desenvolvimento (IST-ID)

PTDC/BIM-MEC/3133/2014

Prion Diseases as a paradigm for protein misfolding diseases
Joana Isabel Araújo de Macedo
Universidade do Algarve (UAlg)

PTDC/BIM-MEC/3194/2014

Physiological Determinants of Nasal Polyposis
NUNO MANUEL BARREIROS NEUPARTH
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/3205/2014

A new mechanism for selective protein loading into exosomes

Jose Silva Ramalho
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/3333/2014

Unveiling the role of extracellular vesicles as novel mechanisms of vascular calcification in CKD
Carla Alexandra São Bento Viegas
Centro de Ciências do Mar (CCMar)

PTDC/BIM-MEC/3351/2014

Signaling Repertoire of beta 2-Adrenergic Receptor Biased Ligands: Physiological Effects in Bone Health and Disease.
Inês Soares Alencastre
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MEC/3468/2014

Theoretical and experimental approaches to the effect of CYP3A4, CYP3A5 and CYP2C19 variability on cardiovascular diseases.
Paulo José Martel
Universidade do Algarve (UAlg)

PTDC/BIM-MEC/3471/2014

Promoting axon regeneration and microglial neuroimmune function in Amyotrophic Lateral Sclerosis
Ana Rita Mendonça Vaz Botelho
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/3497/2014

AutoGRAf - AUTONOMIC INFLUENCE UNDERPINING TO THE GENESIS AND RECURRENCE OF ATRIAL FIBRILATION IN METABOLIC SYNDROME
Maria Isabel de Sousa Rocha
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/BIM-MEC/3503/2014

Multisite Microelectrode Arrays and Oxymetry in Clinical Research as a Tool for Epileptic Foci Localization.
Ana Ledo
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/3588/2014

The mitochondriomics of LHON: disclosing intracellular organelle crosstalk and tailored bigenomics-phenomics algorithm
Manuela Grazina
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/3607/2014

Searching for novel biomarkers in unexplained male infertility
Sandra Catarina Gomes Amaral
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/3627/2014

Central modulation of Sympathetic Nervous Activity as a prospect treatment for Heart Failure
Vera Lúcia Poço Geraldes
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/BIM-MEC/3689/2014

“Estrogen connections” in the human testis: a link between apoptosis and infertility?
Sílvia Cristina da Cruz Marques Socorro
Universidade da Beira Interior (UBI)

PTDC/BIM-MEC/3713/2014

Unraveling possible effects of endocrine disruptors on the progress of pregnancy hypertension and preeclampsia
Ignacio Verde
Universidade da Beira Interior (UBI)

PTDC/BIM-MEC/3749/2014

Nonsense-mediated mRNA decay in genetic diseases and cancer: key players, mechanisms, and a novel approach for suppression therapy
Luísa Romão
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/BIM-MEC/3797/2014

Early diagnosis of exudative age-related macular degeneration (AMD): how to avoid unnecessary loss of vision?
Rufino Martins da Silva
Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI)

PTDC/BIM-MEC/3806/2014

Crosstalk in the airways: bronchial cells and immune cells interactions as determinants of chronic respiratory diseases
Fernando Aguilar Arosa
Universidade da Beira Interior (UBI)

PTDC/BIM-MEC/3864/2014

Cell-based therapy for vascular and neurological repair in stroke
Raquel Margarida da Silva Ferreira
Universidade da Beira Interior (UBI)

PTDC/BIM-MEC/3906/2014

Expression of transcription factors and response to therapy in Multiple Myeloma: identifying effector genetic pathways involved in the response to immunomodulatory therapy
Cristina Maria Godinho Pires João
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/3943/2014

Diabetic retinopathy and mineralocorticoid receptors: it takes two to tango
Paulo Fernando Martins dos Santos
Universidade de Coimbra (UC)

PTDC/BIM-MEC/4146/2014

Muscle wasting in pulmonary arterial hypertension: underlying mechanisms and anti-cachexia approaches
Tiago Alexandre Henriques Coelho
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/4203/2014

Microgliosis under diabetes: impact on axonal transport and memory performance
Filipa Baptista
Universidade de Coimbra (UC)

PTDC/BIM-MEC/4324/2014

Epigenetic Regulation of hTERT in Gliomas: A basis for novel brain tumor therapies
Pedro Castelo Branco
Universidade do Algarve (UAlg)

PTDC/BIM-MEC/4326/2014

Hypomethylation of Histones, Endothelial Dysfunction and Atherosclerosis: Implications for Cardiovascular Disease.

Maria Rita M A Azevedo e Castro
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/4407/2014

New biomarkers for the prediction of preterm birth and its impact on infant health
Ana Maria Pissarra Coelho Gil
Universidade de Aveiro (UA)

PTDC/BIM-MEC/4461/2014

Chronic inflammation phenomes - Integrative approach and risk assessment
Marlene Barros
Universidade Católica Portuguesa (UCP)

P2020-PTDC/BIM-MEC/4507/2014

UROSPHINX - Physiology and mechanics of the male urinary sphincter
Pedro Alexandre Lopes de Sousa Martins
INEGI - Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial (INEGI/UP)

PTDC/BIM-MEC/4556/2014

Renin-angiotensin system: from cardiovascular risk to inflammatory bowel disease?
Manuela Morato
Faculdade de Farmácia da Universidade do Porto (FF/UP)

PTDC/BIM-MEC/4566/2014

Dietary polyphenols as potential modulators of intestinal inflammation: a multitarget strategy for adjunct nutritional therapy?
Leonor Martins Almeida
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/BIM-MEC/4578/2014

The transcription factor Hand2 and microRNAs in the development of RV failure.
Paula Alexandra da Costa Martins
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/4627/2014

Functional analysis of OPTN and SQSTM1 mutations in Paget´s disease of bone
Natércia Conceição
Centro de Ciências do Mar (CCMar)

PTDC/BIM-MEC/4639/2014

Microglia under stress: from plastic dendritic assembly to anxiety - setting the grounds for depression
Catarina Alexandra Reis Vale Gomes
Universidade de Coimbra (UC)

PTDC/BIM-MEC/4665/2014

Molecular Mechanisms of Induced Protection against Sepsis by DNA Damage Responses
LUÍS FILIPE FERREIRA MOITA
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/4727/2014

Unraveling the mysteries of congenital erythrocytosis
Maria Letícia de Sousa Ribeiro
Centro Hospitalar e Universitário de Coimbra, E.P.E. (CHUC)

PTDC/BIM-MEC/4734/2014

EPIMETABAR: Identifying novel EPIgenetic Markers of mETAbolic dysfunction severity and response to BARiatric surgery
Diogo Pestana
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/4753/2014

Mechanisms that regulate the dissemination of circulating tumor cells
Ana Luísa Ferro Espadanal Torres de Magalhães Canha
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/4762/2014

Cellular models for the study of lysosomal dysfunction and correction mechanisms (CeMoLy)
Olga Alcina Martins de Oliveira Amaral
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/BIM-MEC/4778/2014

Microglia dysregulation as trigger for chronic brain inflammation
Joana Esteves Coelho
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/4874/2014

From Human Proteomics to the Development of New Therapeutic Targets for Lung Hypoplasia
CRISTINA ISABEL NOGUEIRA DA SILVA
Universidade do Minho (UM)

PTDC/BIM-MEC/4900/2014

Macrophages control organ homeostasis via Ferritin heavy chain
Birte Blankenhaus
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/4905/2014

Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression.
Duarte Barral
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/4920/2014

Deciphering the IL-10-orchestrated epigenome in myeloid precursor cells: implications for hematologic malignancies
Margarida Saraiva
Universidade do Minho (UM)

PTDC/BIM-MEC/5276/2014

Immunological aging: implications in multiple sclerosis
JOÃO JOSÉ FERNANDES CARDOSO DE ARAÚJO CERQUEIRA
Universidade do Minho (UM)

PTDC/BIM-MEC/5313/2014

Glia purinergic receptors in the pathophysiology of Alzheimer´s disease: the underling mechanisms
Maria da Glória Correia da Silva Queiroz
Faculdade de Farmácia da Universidade do Porto (FF/UP)

PTDC/BIM-MEC/5432/2014

Angiogenic effects of low-dose ionizing radiation to peri-tumoral tissue
Susana Constantino Rosa Santos
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/BIM-MEC/5434/2014

Castration-resistant prostate cancer – An androgen receptor somatic changing landscape – UnIO 03.15
António Manuel Ferreira Araújo
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MEC/5625/2014

Animal Models of resistance/susceptibility to Buruli Ulcer: Transcriptome analysis of Guinea Pigs Infected with Mycobacterium ulcerans
Alexandra Gabriel Fraga
Universidade do Minho (UM)

PTDC/BIM-MEC/5733/2014

Lysosomal exocytosis – a new target to treat the Lysosomal Storage Disorder, Mucopolysaccharidosis type IIIA
Marisa Alexandra Rego Da Encarnação
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/5851/2014

Study of autoreactive 9G4+ B cells in rheumatoid arthritis: Effect of immunossupressive treatment
Rita Alexandra Pedra Aguiar de Moura
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/6083/2014

The renin-angiotensin system as a target for the treatment of diabetic retinopathy
Sónia Daniel Glória Simão
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/6164/2014

Adipose tissue glycation in obesity: more than size, a matter of microvascular function.
Raquel Maria Fino Seiça
Universidade de Coimbra (UC)

PTDC/BIM-MEC/6180/2014

Identification of novel molecular biomarkers and therapeutic targets in Wilms tumour
Luis Miguel Ramos Vieira
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/BIM-MEC/6492/2014

Renal cell carcinoma-derived exosome: the microRNA content as a new disease predictive biomarker and an opportunity to invasive/metastatic disease management
RUI Manuel de MEDEIROS Melo Silva MEDEIROS
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/BIM-MEC/6498/2014

Wall and intraluminal thrombus interplay in abdominal aortic aneurysm – in search of microRNAs as new therapeutical targets (“miRAAA” study)
Sérgio Manuel Moreira Sampaio
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/6502/2014

Gene expression profiling of erythropoiesis disturbance in end-stage renal disease patients resistant to recombinant human erythropoietin therapy
Susana Maria Santos Rocha
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MEC/6523/2014

DETERMINANTS OF LYMPHOPENIA IN SYSTEMIC LUPUS ERYTHEMATOSUS
Maria Francisca Botelho de Gusmao de Moraes de Brito Fontes
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/6554/2014

Hiperhomocisteinemia nas doenças vasculares: causa ou consequência?
Maria Gabriela Machado de Almeida
Egas Moniz - Cooperativa de Ensino Superior, CRL (CESEM)

PTDC/BIM-MEC/6631/2014

Breast cancer therapeutics with Vif
Isabel Maria Corrêa Calvente de Barahona
Egas Moniz - Cooperativa de Ensino Superior, CRL (CESEM)

PTDC/BIM-MEC/6681/2014

Limiting mortality among sepsis patients by the molecular control mechanisms of microcirculation
Maria Carlota Saldanha Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/6688/2014

Endocrine resistance and bone loss in Hormone-dependent Breast Cancer: New aromatase inhibitors and therapeutic targets
Natércia Aurora Almeida Teixeira
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MEC/6700/2014

THE YIN AND YANG ACTION OF THE PANX1-CD39-P2X7 RECEPTOR CLUSTER OPERATING THE NEUROIMMUNOLOGICAL DIALOGUE IN MYASTHENIA GRAVIS
Laura Oliveira
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

P2020-PTDC/BIM-MEC/6911/2014

The interplay between cAMP and Sirtuins as a nexus of mitochondrial and metabolic control
Carlos Palmeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/7138/2014

Role of adenosine A2A receptor in formatting gut microbiota
Paula Margarida Gomes Canas
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/7170/2014

Endothelial dysfunction in atherosclerotic disease of different territories – a contribution to phenotype differentiation.
Rui Manuel Cruz Ferreira
Centro Hospitalar Universitário de Lisboa Central, EPE (CHULC)

PTDC/BIM-MEC/7206/2014

Role of mitofusin-2 in non-alcoholic fatty liver disease and targeting by microRNAs
Rui E Castro
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MET/0121/2014

The sugar and fat metabolic highways to fatty liver disease: where do they meet?
John Griffith Jones
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/1255/2014

Relevance of liver-specific methionine metabolism in sustaining Plasmodium replication
vanessa alexandra zuzarte luis
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MET/1265/2014

Cianobactérias como fonte de compostos bioativos com efeitos sobre morbidades associadas à obesidade - rastreio e mecanismo molecular
Ralph Urbatzka
Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR)

PTDC/BIM-MET/1622/2014

New perspectives to study iron metabolism in atherosclerosis
LUCIANA MARIA GONÇALVES DA COSTA
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/BIM-MET/1792/2014

MicroRNA-mediated modulation of hypothalamic neurogenesis as therapeutic approach for obesity
Ligia Maria de Sousa Ferreira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/1866/2014

Influence of nutrition and genetic variability in DNA methylation: their role in myelodysplastic syndrome development and progression
Ana Bela Sarmento Ribeiro
Universidade de Coimbra (UC)

PTDC/BIM-MET/2023/2014

Immune neutralization of ghrelin activity for obesity treatment and weight maintenance
Mariana Monteiro
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MET/2058/2014

Obesity and type 2 diabetes next-generation genomic characterization towards the development of novel diagnostic tools and treatment algorithms
Paula Maria Vieira Jorge
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MET/2115/2014

Inflamação hepática, clearance da insulina e hiperinsulinemia: uma tríade na base da prediabetes.
Maria Paula Borges de Lemos Macedo
Faculdade de Ciências Médicas (FCM/UNL)

P2020-PTDC/BIM-MET/2123/2014

Novel anti-obesity therapy: melanocortins induction of beige adipocytes
Alexandra Maria Monteiro Gouveia
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/2210/2014

Sirtuin crosstalk in the epigenetic regulation of age-related endothelial dysfunction
Delminda Gamelas Neves Lopes de Magalhaes
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/2351/2014

Dietary anthocyanins: the unexploited connection between Bioavailability, Microbiota and Obesity
Iva Luzia Reis Fernandes
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MET/2505/2014

Enhancing fatty acid oxidation to improve obesity-induced diabetes and wound healing
Andreia Sofia Matos Madeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/2641/2014

Causes for an altered plasma aminothiol profile in Azorean subjects
Maria Leonor Pereira de Almeida Pavão Sequeira de Medeiros
Fundação Gaspar Frutuoso, FP (FGF)

PTDC/BIM-MET/3262/2014

Neuroprotection by natural products from food: role of Mediterranean diet
Rui Fernando Marques da Silva
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MET/3276/2014

From the vagus nerve to the ventral tegmental area: A pathway for postingestive food reinforcement in the development and treatment of obesity.
Ana Fernandes
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/BIM-MET/3337/2014

Mitochondrial regulation of epigenetics and its role in human diseases
Valdemar de Jesus Conde Máximo
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MET/3390/2014

CEPhysOB – EFFECT OF PHYSALIS L. EXTRACT IN OBESITY
Renata Catarina Gonçalves Ramalho
Egas Moniz - Cooperativa de Ensino Superior, CRL (CESEM)

PTDC/BIM-MET/3461/2014

NADPH oxidase subunit Ncf1 as a critical factor in Chronic Inflammation and Cardiac Disease
Maria Margarida Souto Carneiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/3739/2014

Citrus bioactive compounds for targeting human colorectal cancer stem cells
Ana Teresa de Carvalho Negrao Serra
Instituto de Biologia Experimental e Tecnológica (IBET)

PTDC/BIM-MET/3750/2014

Optogenetic dissection of neural circuits controlling adiposity
Ana Domingos
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MET/3854/2014

InMind: INterplay between MIcrobiota and Neuroinflammation: what can we learn from flavonoiD modulation?
Ana Faria
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/3856/2014

Impact of lipid profile and adipose tissue characteristics on bariatric surgery outcomes.
Rita Negrão
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/4125/2014

AN HOLISTIC APPROACH TO THE CONNECTIONS BETWEEN DIETARY REGIMENS AND HEALTH AND THE MECHANISMS BEHIND IT
Miguel Ângelo Rodrigues Pinto de Faria
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MET/4265/2014

Prognostic and Protective Roles of the Clusterin-PON1 axis Against Obesity Complications
JOAO FILIPE CANCELA DOS SANTOS RAPOSO
Associação Protectora dos Diabéticos de Portugal (APDP)

PTDC/BIM-MET/4266/2014

Natural mineral-rich water in obesity and menopause: effects in blood and adipose tissue metabolic, hormonal, biochemical and inflammatory dysfunction
Maria João dos Reis Conceição Martins Almeida Ribeiro
Faculdade de Medicina da Universidade do Porto (FM/UP)

P2020-PTDC/BIM-MET/4447/2014

Crosstalk between perivascular adipose tissue and blood vessels in obesity and vascular dysfunction
Cristina Maria Tristão Sena
Universidade de Coimbra (UC)

PTDC/BIM-MET/4448/2014

Usefulness of teeth trace elements in forensic human identification
Inês Alexandra Costa de Morais Caldas Paiva
Cooperativa de Ensino Superior Politécnico e Universitário, CRL (CESPU)

PTDC/BIM-MET/4459/2014

METSYSWEET: Metabolic syndrome programming by exposure to non-nutritive sweeteners during pregnancy and lactation
Elisa Oliveira Braga Keating
Universidade Católica Portuguesa (UCP)

PTDC/BIM-MET/4471/2014

Metabolic consequences of an infection by African trypanosomes
Luisa M Figueiredo
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

P2020-PTDC/BIM-MET/4712/2014

Obesitility – Gut hormones and testicular metabolism: mechanisms associated with obesity-related male infertility
Marco G Alves
Universidade da Beira Interior (UBI)

PTDC/BIM-MET/4771/2014

Development of redox therapy targeting the phosphatase PTP1B in type-2 diabetes
Fernando José Nunes Antunes
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-MET/4841/2014

Nutraceutic anticancinogenic activities of legume against colon cancer
Regina Maria Fonseca da Luz Freitas
Instituto Superior de Agronomia (ISA/ULisboa)

PTDC/BIM-MET/5510/2014

From sensitivity to food preferences and choice: salivary biomarkers of astringency perception and psychosocial and market related determinants evaluation
Elsa Lamy
Universidade de Évora (UE)

PTDC/BIM-MET/5529/2014

Mechanistic and dietary approaches for Alzheimer’s and brain aging via modulation of the neurovascular-neuroenergetic coupling axis by nitric oxide
João António Nave Laranjinha
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/5553/2014

Gut Microbiome and Metabolism: The Impact of a Gluten-Free Diet
Paulo Manuel de Castro Pinho e Costa
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/BIM-MET/5925/2014

Rewarding the adipose tissue: dopaminergic signaling as a modulator of adipocyte function.
Paulo Nuno Centeio Matafome
Universidade de Coimbra (UC)

PTDC/BIM-MET/6155/2014

Metabolic Syndrome and visceral adiposity impact in colon cancer patients
Gil Filipe Ramada Faria
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MET/6235/2014

Life style and Diabetes: study of effectiveness of a muldimensional intervention health program introducing telemetry as strategy
Pedro Parreira
Escola Superior de Enfermagem de Coimbra (ESEnfC)

PTDC/BIM-MET/6330/2014

Benefits assessment of microalgae consumption in elderly: An in vitro and in vivo study of the bioaccessibility and bioavailability of key healthy nutrients and bioactive compounds in ageing
Cláudia Afonso
Instituto Português do Mar e da Atmosfera, I. P. (IPMA)

PTDC/BIM-MET/6488/2014

Iron homeostasis in postmenopausal and osteoporosis risk associated with the metabolic syndrome: nutrigenetic contribution
Maria Isabel Augusta Cortes do Carmo
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/BIM-MET/6583/2014

mi(RNA)tochondria: A role for miRNAs as the initiators of metabolic disease?
Filipe Valente Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/6889/2014

Gliptins as anti-fibrotic agents: a new approach on obesity treatment
Joana Salgado
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/6903/2014

A new hope for obesity and diabetes: The role of metabolic fluxes in bile acid-mediated improvement of metabolism
João Paulo Soeiro Terra Teodoro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/7041/2014

Farnesoid X receptor variants - understanding multitasking in metabolic control
Vera Ribeiro Marques
Universidade do Algarve (UAlg)

PTDC/BIM-MET/7103/2014

Normal and Pathogical Metabolism and Hippocampal Neuronal Activity
Pedro Afonso dos Santos Baltazer de Lima
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MED/0032/2014

The non-coding transcriptome in stemness and aging
Bruno Bernardes de Jesus
Universidade de Aveiro (UA)

P2020-PTDC/BIM-MED/0075/2014

Mechanisms underlying hemogenic induction in human fibrobalsts
Carlos Filipe Ribeiro Lemos Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/0368/2014

Unraveling signaling targets for effective neuroregenerative strategies
Sandra Isabel Moreira Pinto Vieira
Universidade de Aveiro (UA)

PTDC/BIM-MED/0394/2014

Targeting Mitochondria Bioenergetics to Improve Aging-Impaired Neurogenesis
Susana Zeferino Solá da Cruz
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MED/0490/2014

Caracterização dos eventos cardiogénicos precoces para derivação de progenitors cardíacos a partir de células estaminais pluripotentes
José Bragança
Universidade do Algarve (UAlg)

PTDC/BIM-MED/0605/2014

Low oxygen conditioning of the Stromal Vascular Fraction of Adipose Tissue to produce prevascularized osteogenic Cell Sheet constructs.
Rogério Pirraco
Universidade do Minho (UM)

PTDC/BIM-MED/0659/2014

Cell plasticity and reprogramming during tissue regeneration
Antonio Alfredo Coelho Jacinto
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MED/0947/2014

BBB-permeable nanoparticles loaded with CDNF for Parkinson’s disease therapy.
LILIANA INÁCIO BERNARDINO
Universidade da Beira Interior (UBI)

PTDC/BIM-MED/1789/2014

Mesenchymal stem cells: a novel preventive strategy for spinocerebellar ataxia type 3 or Machado-Joseph disease?
Catarina Sofia Oliveira Miranda
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/1980/2014

Stem cell therapy in bladder underactivity
Ana Cristina Martins Pinto Coelho
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MED/2047/2014

ANGIOVESICLES - Construction of a library of pro-angiogenic vesicles for therapeutic use in regenerative medicine
Joana Correia
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/2384/2014

Mesenchymal Stem Cells secretome as a strategy for intervertebral disc regeneration
Raquel Madeira Gonçalves
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MED/2664/2014

Reconstituting T lymphocytes through the generation of artificial thymus: a tissue engineering strategy
Margarida Correia-Neves
Universidade do Minho (UM)

PTDC/BIM-MED/2848/2014

New potential therapy for multiple sclerosis: a role for adenosine A2A receptors
Sara Xapelli
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MED/2944/2014

PERI-TARGETS: dissecting the pericardial fluid as new mediator in cardiac response to myocardial infarction
Diana Esperança dos Santos Nascimento André
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MED/3076/2014

Mechanistic and optogenetic control of astroglia for neural repair
Federico Herrera
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

PTDC/BIM-MED/3124/2014

The “ECM” memories in Parkinson’s disease. Can ECM components aid in dopaminergic neuron graft success in a model of Parkinson’s disease?
María Gómez Lázaro
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MED/3295/2014

Angiocrine factors as modulators of spinal cord regeneration
Maria Leonor Tavares Saúde
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MED/3363/2014

Control of cardiomyocyte proliferation in disease and regenerative medicine
José António Henriques de Conde Belo
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MED/3505/2014

Human iPS-derived NSC transplantation in MJD
Liliana Simões Mendonça
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/3888/2014

Development of biomimetic approaches to enhance flexor tendon regeneration
Márcia Teresa Silva Rodrigues
Universidade do Minho (UM)

P2020-PTDC/BIM-MED/4041/2014

Sensory innervation in the complex orchestration of bone regeneration: interplay in microfluidics platforms
Meriem Lamghari Moubarrad
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MED/4087/2014

CardEC - pharmacological modulation of microRNAs regulating human cardiomyocyte-endothelial crosstalk..
Hugo Agostinho Machado Fernandes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/4100/2014

Regenerating the Injured Spinal Cord by Modulating Glial Scar Formation and Mesenchymal Stem Cells Secretome
António José Braga Osório Gomes Salgado
Universidade do Minho (UM)

PTDC/BIM-MED/4111/2014

Diabetes, Cardiomyopathy and Cardiac Regeneration
Luis Afonso Bras Simoes Rosario
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/BIM-MED/4126/2014

Ensaio pré-clínico de regeneração óssea induzida por células tronco mesenquimatosas humanas activadas por purinas
Paulo Correia de Sá
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MED/4240/2014

Stem Cells Anti–Aging and Differentiation through Biomaterials Design
Sara Maria Marques de Oliveira
Universidade do Minho (UM)

PTDC/BIM-MED/5216/2014

The endothelial progenitor cell secretome as a therapeutic approach for Diabetes and Alzheimer Disease
Ana Burgeiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/6157/2014

Angiocrine Notch-ligand signals regulate hepatic stellar fate: impact on liver fibrosis and regeneration.
Hélia Cristina Oliveira Neves
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MED/6260/2014

Metabolic Modulation and epigenetics: Can we make more neurons?
Sandro Lino Cardoso Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/6397/2014

Impact of microRNAs in skeleton formation and regeneration
Daniel António Martins Tiago
Centro de Ciências do Mar (CCMar)

PTDC/BIM-MED/6562/2014

WIDECORD - Widening umbilical cord blood transplantation through integrated ex-vivo expanded cell-based therapies
João Mascarenhas Forjaz de Lacerda
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MED/6698/2014

SKELmCELL - Skeletal muscle regeneration through the application of cellular therapies in association to biomaterials - Mesenchymal stem cells and hydrogel vehicle systems
Tiago de Melo Silva Ramos Pereira
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/BIM-MED/6854/2014

Endothelial progenitor cells in neoangiogenesis of Acute Ischemic Stroke
Luis Augusto Salgueiro Cunha
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/7159/2014

Assessment of the role of FBXL5 on the maintenance of embryonic stem cells’ pluripotency and differentiation
Gisela Sofia Mendes Machado de Oliveira
Universidade do Algarve (UAlg)