Skip nav

R&D Projects

Confirmed projects database queries

The information may be unavailable due to the results not being approved or confirmed. In particular, when a call includes regions where projects are cofunded by EC funds and others where that is not the case, confirmation or approval may be not simultaneous.

Proposals for Research and Development Projects in all Scientific Domains - 2004

Health Sciences - Molecular Medicine

    Painel de Medicina Molecular - 2004
  • Frank Grosveld
  • Leif Carlsson
  • Hernando A. del Portillo
  • Goran Moller
  • Irun Cohen
  • Matthew Wood
POCI/SAU-MMO/55374/2004

Neuronal Ceroid Lipofuscinosis: Molecular, biochemical and functional studies. Maria Gil Roseira Ribeiro, Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ). €65,021.

POCI/SAU-MMO/55476/2004

Impact of mRNA mistranslation on cell degeneration and evolution. Manuel António Silva Santos, Universidade de Aveiro (UA). €94,717.

POCI/SAU-MMO/55919/2004

Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis. Elsa Margarida Teixeira Rodrigues, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €49,730.

POCI/SAU-MMO/55955/2004

Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators. Dora Brites, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €79,524.

POCI/SAU-MMO/55974/2004

Tolerance induction in autoimmunity: reprogramming the immune system with monoclonal antibodies. Luis Ricardo Silva Graca, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €85,219.

POCI/SAU-MMO/56055/2004

Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs. LUÍS FERNANDO MORGADO PEREIRA DE ALMEIDA, Centro de Neurociências e Biologia Celular (CNBC/UC). €30,000.

POCI/SAU-MMO/56066/2004

Modulation of atherosclerosis by the protective gene heme oxygenase-1: Molecular mechanisms and therapeutic applications. Miguel Amado Franco Parreira Soares, Fundação Calouste Gulbenkian (FCG). €63,335.

POCI/SAU-MMO/56163/2004

Proteomics of Chronic Lung Diseases Leading to Biomarkers and Therapeutic Target Discovery. Deborah Penque, Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ). €94,932.

POCI/SAU-MMO/56387/2004

Molecular Genetics of Autosomal Dominant Neurodegenerative Diseases Characterized mainly by Ataxia. Isabel Alexandra Azevedo Silveira, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,997.

POCI/SAU-MMO/56439/2004

Molecular pathways involved in Gordon syndrome, a familial hypertension disease. Peter Jordan, Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa). €20,520.

POCI/SAU-MMO/56774/2004

Multiple isoforms of CD6 that arise from alternative splicing: their role in the regulation of T cell signaling and at the immunological synapse. Alexandre Carmo, Instituto de Biologia Molecular e Celular (IBMC/UP). €91,079.

POCI/SAU-MMO/57052/2004

Somatic expression of PDHA2 gene - a long dreamed therapy. Isabel Maria Antolin Martins-de-Carvalho, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €59,309.

POCI/SAU-MMO/57216/2004

Filling in the GAP: the missing link between intercellular communication and diabetic retinopathy. Paulo Pereira, Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI). €39,338.

POCI/SAU-MMO/57321/2004

Search for TTR ligands modulators of amyloidogenesis. Maria Rosário Almeida, Instituto de Biologia Molecular e Celular (IBMC/UP). €81,831.

POCI/SAU-MMO/57573/2004

Study of the mechanism by which the proximity of the nonsense codon to the AUG inhibits the nonsense-mediated mRNA decay. Luísa Romão, Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa). €34,382.

POCI/SAU-MMO/57598/2004

Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal. Eugenia Carvalho, Centro de Neurociências e Biologia Celular (CNBC/UC). €73,750.

POCI/SAU-MMO/57700/2004

Regulation of mRNA processing and transport within the nucleus. Maria Carmo-Fonseca, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €43,000.

POCI/SAU-MMO/57936/2004

Bile Acid Mediated Inhibition of Neuronal Apoptosis. Cecília Maria Pereira Rodrigues, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €60,427.

POCI/SAU-MMO/57955/2004

Type 1 Diabetes: immunopathology and genetic susceptibility. Carlos Augusto Gomes Barbosa da Penha Gonçalves, Fundação Calouste Gulbenkian (FCG). €53,600.

POCI/SAU-MMO/58192/2004

Inflammatory components in the biology of regulatory T cells and the prevention of auto-immune disease. Jocelyne Demengeot, Fundação Calouste Gulbenkian (FCG). €47,500.

POCI/SAU-MMO/58353/2004

In Vivo Molecular Dissection of Mitotic Spindle Morfogenetic Pathways - Implications for Aneuploidy and Cancer. Helder Jose Martins Maiato, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,984.

POCI/SAU-MMO/58413/2004

Study of genetic diversity of the Azorean population. Luisa Maria Quental Mota Vieira, Hospital do Divino Espírito Santo de Ponta Delgada, EPE (HDESPD, EPE). €49,920.

POCI/SAU-MMO/58425/2004

CFTR Interactome. Margarida Sofia Pereira Duarte Amaral, Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa). €82,604.

POCI/SAU-MMO/59370/2004

Efflux-pumps in drug resistance of Mycobacterium tuberculosis: Molecular characterisation of the efflux mechanism and use of efflux inhibitors as new anti-tubercular compounds. Miguel Viveiros Bettencourt, Instituto de Higiene e Medicina Tropical (IHMT/UNL). €52,350.

POCI/SAU-MMO/59444/2004

Mechanism and Utility of a Novel Herpes Virus Gene Inducing Apoptosis. Robert Michael Evans Parkhouse, Fundação Calouste Gulbenkian (FCG). €61,189.

POCI/SAU-MMO/59607/2004

Genomic and post-genomic in-depth molecular characterization of the RAS/RAF/ERK and the PI3 Kinase/AKT signalling transduction pathways in aggressive thyroid tumours. Ginesa Garcia Rostan, Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP). €93,100.

POCI/SAU-MMO/59725/2004

Characterisation and applications of a novel hemangioblast-specific transcriptional enhancer. Ana Teresa Fernandes Nunes Tavares, Fundação Calouste Gulbenkian (FCG). €46,500.

POCI/SAU-MMO/59913/2004

Autoantibody repertoires and regulatory T-cells in human and murine lupus. Constantin Fesel, Fundação Calouste Gulbenkian (FCG). €57,000.

POCI/SAU-MMO/59997/2004

Cell cycle checkpoints during human oocyte meiosis in vitro. Alberto Barros, Faculdade de Medicina da Universidade do Porto (FM/UP). €66,092.

POCI/SAU-MMO/60156/2004

Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph´s disease. Sandra de Macedo Ribeiro, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,996.

POCI/SAU-MMO/60333/2004

T cell production in HIV immunodeficiency. Ana Espada de Sousa, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €72,417.

POCI/SAU-MMO/60412/2004

Study of the involvement of the molecular chaperones and the ubiquitin-proteasome system in Machado-Joseph disease. Patrícia Espinheira de Sá Maciel, Universidade do Minho (UM). €77,900.

POCI/SAU-MMO/60419/2004

Hoxb4 in the formation of hematopoietic stem cells. Moises Mallo, Fundação Calouste Gulbenkian (FCG). €43,252.

POCI/SAU-MMO/60443/2004

Listeria as a model for the analysis of pathogen and host factors that determine the fate of infections. Didier Cabanes, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,833.

POCI/SAU-MMO/60555/2004

Genomic Imprinting in human spermatogenesis. Mário Manuel da Silva Leite Sousa, Faculdade de Medicina da Universidade do Porto (FM/UP). €73,920.

POCI/SAU-MMO/60709/2004

Gene expression profiles in stage specific male germ cells using the microarray technology. Filipa Abreu Gomes de Carvalho, Faculdade de Medicina da Universidade do Porto (FM/UP). €39,713.

POCI/SAU-MMO/60930/2004

Functional genomics in malaria - an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmodium sporozoite fully development inside hepatocytes. Maria Manuel Dias da Mota, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €85,525.

POCI/SAU-MMO/61129/2004

Expression and Function of Ubiquitin Conjugating Enzyme hsUbc6e. John Vincent Fleming, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €22,000.

POCI/SAU-MMO/61547/2004

Impact of diabetes mellitus on myocardial remodeling induced by cardiac overload and ischemia. Joaquim Adelino Correia Ferreira Leite Moreira, Faculdade de Medicina da Universidade do Porto (FM/UP). €62,605.

POCI/SAU-MMO/61652/2004

Regulation of IL-10 Expression at the allel level. Matthias Haury, Fundação Calouste Gulbenkian (FCG). €57,000.

POCI/SAU-MMO/62964/2004

Genetics of the Innate Immune Response in the Non-Obese Diabetic Mouse. Carlos Augusto Gomes Barbosa da Penha Gonçalves, Fundação Calouste Gulbenkian (FCG). €60,000.

POCI/SAU-MMO/63284/2004

The Cell Biology and Molecular Basis of Neural Tube Closure in the Chick Embryo. Joaquin Maria Rodriguez-Leon, Fundação Calouste Gulbenkian (FCG). €61,246.