ERDERA European Partnership Call 2026

The European Rare Diseases Research Alliance (ERDERA) has been established to help in coordinating the research efforts of European and non-European countries in the field of rare diseases and implement the objectives of the International Rare Disease Research Consortium (IRDiRC).

The ERDERA 2026 call aims to tackle rare disease (RD) patient-need led challenges and enable scientists to build, based on common interests and sharing of expertise, effective, multinational, interdisciplinary research collaborations. The expected impact lies in the future translation and use of the results to the benefit of patients.

Under the general theme of «Resolving unsolved cases in rare genetic and non-genetic Diseases», this call aims to solve Undiagnosed Rare Genetic diseases and to address complex, multifactorial Rare Non-Genetic diseases by identifying causative variants in patients with no molecular diagnosis after prior genetic or genomic testing and providing diagnostic clarity for conditions of unknown or mixed pathogenesis.

Suggested focus areas are:

• Functional validation to classify Variants of Uncertain Significance (VUS) and increase the diversity of functional genomics research, or validation of candidate VUS to improve outcomes for a broader range of patients using in silico, in vitro or animal model systems (e.g. CRISPR modified cells, iPSCs, organoids, etc.);
• Use of multi-omics or integrative methods (e.g. transcriptomics, epigenomics, etc.) to resolve ambiguous or complex variants;
• New tools/methodologies not yet validated in clinical settings, including biostatistics, advanced bioinformatics, and mathematics approaches (e.g. variant effect predictors, Artificial Intelligence (AI)-based annotation platforms, etc.);
• Systems biology and disease mechanism modelling;
• Integration of clinical, environmental, lifestyle, and sensor-derived data;
• Development of knowledge graphs or disease maps to link phenotypic and mechanistic insights;
• Use of advanced AI and modelling tools (graph ML, probabilistic causal models).

The following are individual or co-promotion beneficiaries:

           a) Non-entrepreneurial entities of the R&I system, namely:
              i. Higher education institutions, their institutes and R&D units.
             ii. State, Associated or International Laboratories with head office in Portugal.
            iii. Non-profit private institutions whose main object is R&D activity, including Collaborative Laboratories (CoLab) and Technology
                 and Innovation Centres (TIC).
             iv. Other non-profit public and private institutions developing or participating in scientific research activities.

            b) Companies of any type and under any legal form.

The information contained in this section does not exempt you from consulting Article 3 of FCT’s Regulation No. 999/2016, in its current wording, i.e., as amended and republished by Regulation No. 5/2024 and corrected by Rectification Statement No. 366/2024/2, of 23 May 2024 (see FCT Regulation in Call Documents and the applicable national and European Union legislation).

This call consists of the submission of pre-proposals (1st phase) and full proposals (2nd phase). Only the pre-proposals submitted by the transnational consortia in the 1st phase may be invited to submit full proposals in the 2nd phase.

Each Proposing Institution (PI) that is part of a transnational consortium can only apply for funding from the Participating Funding Agencies (PFA) of its country or region. See the Call Text and the Guidelines for Applicants (under Call Documents), for information on the eligibility rules of each PFA and on the transnational eligibility rules. For a proposal to be eligible, it must comply with the national and transnational eligibility rules.

To submit their application, each Portuguese PI wishing to apply for funding from FCT should:

1. Consult the Call Documents area.
2. Consult FCT eligibility rules (see the Guideline for Applicants)).
3. Submit, by the transnational consortium coordinator, the proposal form on the application submission platform (see Important links) until 13:00 GMT in mainland Portugal on 12/02/2026.
4. Send to FCT, within 10 working days after the deadline for submitting the application, a Statement of Commitment (SoC) completed and signed by the Portuguese Researcher in Charge (RC) identified by the PI and by a qualified representative of the PI. The SoC should be sent to the email address indicated in Contacts.

Please note:

• Failure to send the SoC to FCT on the date referred to in paragraph 4, or the unjustified delivery of the SoC after that deadline, or the delivery of an incomplete SoC, without one of the two parts – RC and PI – that make it up or without the signatures of the Portuguese RC and/or a qualified representative of the Portuguese PI, will result in the application being declared ineligible.
• If more than one Portuguese applicant from the same transnational consortium applies for funding from FCT, each must send a completed and signed SoC to FCT.
• One SoC must be sent to FCT for each application submitted by the same RC and PI.
• Portuguese partners of transnational consortia that do not apply for funding from FCT do not need to submit the SoC to FCT.
• The PI stamp or white seal is only required on manually signed SoC.

The information on this page is only a summary of the call, does not exempt the candidates from carefully reading all the call documents available on this page and on the call website (see Important links) and refers only to FCT’s participation in this call, unless expressly indicated.

Eligibility

The eligibility check of applications is carried out at both stages of the call (pre-proposal submission stage and full proposal submission stage):

• National/Regional Funding Agencies check national eligibility of applications, ensuring compliance with the formal requirements in the applicable national/regional regulations and other applicable documents (see FCT Regulation, Normas de execução financeira and national annexes in the Call Documents area).
• Transnational eligibility check of applications will be performed by the Call Secretariat, according to the transnational eligibility criteria presented in the Call Text in the Call Documents area.

Please note:

• For a proposal to be declared eligible it must fulfil both the national and transnational criteria.

Evaluation

The call includes two evaluation phases:

• Pre-proposal evaluation stage.
• Full proposal evaluation stage.

Proposals will be evaluated according to the evaluation criteria described in the Call Text in the Call Documents area.

The participating national/regional funding agencies, will decide, according to the stage the call is at, which 1) pre-proposals to invite to submit a full proposal and which 2) proposals to recommend for funding.

• FCT financial commitment for the call: 350.000,00€
• Maximum requested funding for a consortium with Portuguese coordination: 150.000,00€
• Maximum requested funding for a consortium with Portuguese participation: 100.000,00€

Please note:

• Portuguese institutions funding must follow FCT’s Regulation No. 999/2016, in its current wording, i.e., as amended and republished by Regulation No. 5/2024 and corrected by Rectification Statement No. 366/2024/2, of 23 May 2024 (see FCT Regulation and Normas de execução financeira in Call Documents and the applicable national and European legislation).
• If more than one Portuguese applicant from the same transnational consortium applies for funding from FCT, the combined budget requested from FCT by the Portuguese applicants may not exceed the maximum funding limit for a consortium with Portuguese coordination (150.000,00€) or with Portuguese participation (100.000,00€). The Portuguese applicants of the same transnational consortium will have to share the funding that will be granted by FCT.
• The dedication (FTE) in transnational projects is not considered for the 100% (FTE) dedication to national projects.
• Under the terms of number 2 of Article 7 of the Regulation on projects funded solely by national funds, payments made directly or indirectly to companies through the Proposing Institution cannot exceed 50% of the total cost of the company’s participation.

• Call website
• Application submission platform (available soon)
• Partnership website
• Partnership page on the FCT website

Rita Cavaleiro
Pedro Ferreira

erdera@fct.pt